Supplementary Figure 5: No deficits in task performance above > 10% contrast (corresponds to data in Fig. 1).
a. To investigate whether Fmr1-/- mice have impairments in basic visual discrimination, we randomly presented drifting gratings of varying contrast, from 0% to 100%, and tested mice of both genotypes that had already reached a d’ > 2 at 100% contrast on the visual discrimination task with 90o as the angle difference between preferred and non-preferred directions. b. Representative cumulative histograms of % correct responses from a WT and a Fmr1-/- mouse at different contrasts (data in panels b-d is for mice after they learned the basic 90o task). c. There were no significant differences in task performance between WT and Fmr1-/- mice when the contrast for gratings was > 10%. p = 0.6, Two-sided Mann-Whitney test.n = mice, Fmr1-/-(5), WT (4). d. Mice that had learned the task at 100% contrast then performed poorly (d’ < 2) below a certain contrast threshold and Fmr1-/- mice had a higher contrast threshold than WT mice. n = mice, Fmr1-/-(5), WT (4). p = 0.043, Two-sided Mann-Whitney test.
