Supplementary Figure 2: Impact of miR-137 on embryonic and postnatal development. | Nature Neuroscience

Supplementary Figure 2: Impact of miR-137 on embryonic and postnatal development.

From: Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Supplementary Figure 2

a, Morphology of miR-137 gKO embryos. Timed mating occurred using heterozygous × heterozygous. Embryos at embryonic day 15.5 (E15.5) were collected, and no apparent morphological difference among Mir137+/+, Mir137+/– and Mir137–/– mice were found. b, At the postnatal day 0 (P0), Mir137+/+ and Mir137–/– mice were similar regarding size/weight. c, The major organs (heart, liver, lung, and kidney) of Mir137–/– mice at P14 are smaller than those of Mir137+/+ and Mir137+/– littermates. d, Histopathological examinations of heart, liver, lung, and kidney tissues (H&E staining, 20X) showed no apparent differences in organs’ histological sections among each genotype. All the experiments were repeated independently at least three times with similar results.

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