Supplementary Figure 10: Significant overlap exists between downregulated proteins and PSD–PSD95 complex proteins. | Nature Neuroscience

Supplementary Figure 10: Significant overlap exists between downregulated proteins and PSD–PSD95 complex proteins.

From: Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Supplementary Figure 10

(a) Proteomic analysis identified 417 differentially expressed (DE) proteins (377 genes) in Mir137–/– mice compared to Mir137+/+ mice. By overlapping with previously reported PSD/PSD95 core complex proteins (Fernandez et al., 2009), we found a significant fraction of PSD/PSD95 core complex proteins were downregulated in Mir137–/– mice. (b) Many of these downregulated PSD/PSD95 core complex proteins are associated with ASD (in red) and schizophrenia (underlined). (c) A significant fraction of PSD/PSD95 core complex proteins has miR-137 predicted targets. Pearson’s chi-squared test calculated the P-value.

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