Supplementary Figure 12: miRNA regulation of autism spectrum disorder-linked genes.
From: Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development
(a) Bipartite network module magenta is significantly enriched for genes annotated associated with ASD. (b) Expression of two miRNAs associated with ASD33 assayed using sc-qPCR expression. Notably, expression of miR-137 and miR-218 are both highly detected in neurons, with miR-218 also being expressed in progenitors. (c) In situ hybridization for miR-137 and miR-218 in primary tissue sections reveals expression of both miRNAs in the cortical plate. In particular, miR-137 appears to be expressed in maturing excitatory neurons at midgestation. ** FDR<0.05.
