Supplementary Figure 2: LC activation increased thalamic feature selectivity and improved information transmission.

(a) Population average of peak-to-peak amplitude of significant features for VPm neurons under varying LC stimulation conditions (1.49±0.22 without LC stimulation vs 1.85±0.28 during 2 Hz LC stimulation and 2.38±0.36 during 5 Hz LC stimulation, n=41 features across 22 neurons across 15 animals, Bonferroni corrected α=0.025, p=1.3x10^-6 and =2.5x10^-8 respectively, Wilcoxon signed-rank test). Each circle represents a significant feature. (b) Population average of information transmission efficiency (bits/spike) for VPm neurons under varying LC stimulation conditions (0.15±0.03 bits/spike without LC stimulation vs 0.32±0.12 bits/spike during 2 Hz LC stimulation and 0.60±0.16 bits/spike during 5 Hz LC stimulation, n=41 features across 22 neurons across 15 animals, Bonferroni corrected α = 0.025, p=6.7x10^-6 and =2.5x10^-8 respectively, Wilcoxon signed-rank test). Each circle represents a significant feature. (c) Population average of information transmission rate (bits/second) for VPm neurons under varying LC stimulation conditions (0.97±0.17 bits/sec without LC stimulation vs 1.43±0.37 bits/sec during 2 Hz LC stimulation and 2.0±0.40 bits/sec during 5 Hz LC stimulation, n=41 features across 22 neurons across 15 animals, Bonferroni corrected α = 0.025, p=3.0x10^-3 and =2.5x10^-6 respectively, Wilcoxon signed-rank test). Each circle represents a significant feature. Error bars indicate ±s.e.m.