Supplementary Figure 3: Optogenetic LC stimulation improved thalamocortical information transmission. | Nature Neuroscience

Supplementary Figure 3: Optogenetic LC stimulation improved thalamocortical information transmission.

From: Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics

Supplementary Figure 3

(a) Example of recovered features for a VPm neuron under varying LC photostimulation conditions. Inset: the nonlinear tuning functions of the same neuron. (b) Population average of information transmission efficiency (bits/spike) for VPm neurons under varying LC photostimulation conditions (0.12±0.03 bits/spike without LC stimulation vs 0.26±0.06 bits/spike during 2 Hz LC stimulation and 0.50±0.12 bits/spike during 5 Hz LC stimulation, n=18 features across 10 neurons across 4 animals, Bonferroni corrected α=0.025, p=0.012 and =3.7x10-3 respectively, paired t-test). Each circle represents a significant feature. (c) Population average of information transmission rate (bits/second) for VPm neurons under varying LC photostimulation conditions (1.47±0.59 bits/sec without LC stimulation vs 2.40±0.64 bits/sec during 2 Hz LC stimulation and 3.34±0.88 bits/sec during 5 Hz LC stimulation, n=18 features across 10 neurons across 4 animals, Bonferroni corrected α=0.025, p=0.033 and =0.013 respectively, paired t-test). Each circle represents a significant feature. Error bars indicate ±s.e.m.

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