Supplementary Figure 5: The LC-activation-induced improvement in thalamic information transmission was not inherited from the PrV. | Nature Neuroscience

Supplementary Figure 5: The LC-activation-induced improvement in thalamic information transmission was not inherited from the PrV.

From: Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics

Supplementary Figure 5

(a) Example single-unit PrV response to a punctate stimulation of its principal whisker, with arrow marking stimulation onset. Inset: example PrV waveform; shaded area represents ±s.d. (n=56 spikes) (b) PrV firing rate in response to WGN whisker stimulation under varying LC stimulation conditions (40±5 Hz without LC stimulation vs 39±5 Hz during 2 Hz LC stimulation and 40±5 Hz during 5 Hz LC stimulation, n=13 neurons across 8 animals, Bonferroni corrected α=0.025, p=0.28 and =0.72 respectively, paired t-test). Each circle represents a PrV neuron. (c) Population average of information transmission efficiency (bits/spike) for PrV neurons under varying LC stimulation conditions (2.06±0.65 bits/spike without LC stimulation vs 2.09±0.64 bits/spike during 2 Hz LC stimulation and 2.08±0.63 bits/spike during 5 Hz LC stimulation, n=24 features across 13 neurons across 8 animals, Bonferroni corrected α=0.025, p=0.19 and =0.89 respectively, Wilcoxon signed-rank test). Each circle represents a significant feature. Error bars indicate ±s.e.m.

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