Supplementary Figure 6: Inactivation of the barrel cortex by muscimol injection did not alter LC-activation-induced improvements in thalamic information transmission. | Nature Neuroscience

Supplementary Figure 6: Inactivation of the barrel cortex by muscimol injection did not alter LC-activation-induced improvements in thalamic information transmission.

From: Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics

Supplementary Figure 6

(a) Example single-unit barrel cortex response to a punctate stimulation of its principal whisker, with arrow marking stimulation onset. Inset: example barrel cortex waveform; shaded area represents ±s.d. (n=1398 spikes) (b) Example average LFP response in barrel cortex to a punctate stimulation of the cortical barrel column’s principal whisker before and after muscimol injection. Shaded area represents ±s.e.m (n=313 and =308 trials respectively). Similar results were observed in another animal. (c) Population average of information transmission efficiency (bits/spike) for VPm neurons, post cortical inactivation, under varying LC stimulation conditions (0.33±0.13 bits/spike without LC stimulation vs 0.54±0.18 bits/spike during 2 Hz LC stimulation and 0.90±0.31 bits/spike during 5 Hz LC stimulation, n=8 features across 7 neurons across 4 animals, Bonferroni corrected α=0.025, p=0.017 and =0.028 respectively, paired t-test). Each circle represents a significant feature. Error bars indicate ±s.e.m.

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