Supplementary Figure 7: The LC-activation-induced increase in thalamic information transmission was due to the action of NE in the thalamus.

(a) Population average of information transmission efficiency (bits/spike) for VPm neurons, prior to phentolamine injection, under varying LC stimulation conditions (0.21±0.09 bits/spike without LC stimulation vs 0.75±0.49 bits/spike during 2 Hz LC stimulation and 1.23±0.60 bits/spike during 5 Hz LC stimulation, n=10 features across 6 neurons across 4 animals, Bonferroni corrected α=0.025, p=0.002 and =0.078, respectively, paired t-test). Each circle represents a significant feature. (b) Population average of information transmission efficiency (bits/spike) for VPm neurons, post phentolamine injection, under varying LC stimulation conditions (0.33±0.12 bits/spike without LC stimulation vs 0.32±0.12 bits/spike during 2 Hz LC stimulation and 0.32±0.11 bits/spike during 5 Hz LC stimulation, n=10 features across 5 neurons across 4 animals, Bonferroni corrected α=0.025, p=0.64 and =0.76 respectively, paired t-test). Each circle represents a significant feature. (c) Population average of information transmission efficiency (bits/spike) for VPm neurons, post saline injection, under varying LC stimulation conditions (0.05±0.01 bits/spike without LC stimulation vs 0.10±0.02 bits/spike during 2 Hz LC stimulation and 0.13±0.02 bits/spike during 5 Hz LC stimulation, n=7 features across 4 neurons across 4 animals, Bonferroni corrected α=0.025, p=0.037 and =1.7x10^-4 respectively, paired t-test). Each circle represents a significant feature. Error bars indicate ±s.e.m.