Supplementary Figure 9: LC activation modulated intrathalamic circuit dynamics by reducing burst firing in both the TRN and VPm. | Nature Neuroscience

Supplementary Figure 9: LC activation modulated intrathalamic circuit dynamics by reducing burst firing in both the TRN and VPm.

From: Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics

Supplementary Figure 9

(a) Population average of percent of spikes in bursts for VPm and TRN neurons under varying LC stimulation conditions (VPm: 26±2% without LC stimulation vs 21±2% during 2 Hz LC stimulation and 14±2% during 5 Hz LC stimulation, n=22 neurons across 15 animals, Bonferroni corrected α=0.025, p=3.8x10-4 and =1.1x10-7, respectively, paired t-test; TRN: 17±3% without LC stimulation vs 10±3% during 2 Hz LC stimulation and 8±3% during 5 Hz LC stimulation, n=21 neurons across 10 animals, Bonferroni corrected α=0.025, p=0.031 and =0.007, respectively, paired t-test). (b) Example plots from the same VPm neuron showing inter-spike-intervals (ISIs) before vs after each spike in response to WGN whisker stimulation. Left: without LC stimulation. Right: with 5 Hz LC stimulation. (c) Example single-unit TRN response to a punctate stimulation of its principal whisker, with arrow marking whisker stimulation onset. Inset: example TRN waveform; shaded area represents ±s.d. (n=220 spikes) (d) Example plots from the same TRN neuron showing ISIs before and after each spike in response to WGN whisker stimulation. Left: without LC stimulation. Right: with 5 Hz LC stimulation. Error bars indicate ±s.e.m.

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