Supplementary Figure 11: NE effects on the variance of membrane potential and coefficient of variation of interspike intervals for VPm neurons. | Nature Neuroscience

Supplementary Figure 11: NE effects on the variance of membrane potential and coefficient of variation of interspike intervals for VPm neurons.

From: Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics

Supplementary Figure 11

(a) NE activation in the modelled intrathalamic circuit decreased the variance of membrane potential of VPm neurons (74±4% of the control for NE in both VPm and TRN, n=13 modelled VPm neurons, α=0.05, p=3.9x10-5, paired t-test). (b) Coefficient of variation of VPm inter-spike-intervals under varying LC stimulation conditions (1.56±0.04 without LC stimulation vs 1.57±0.10 during 2 Hz LC stimulation and 1.36±0.05 during 5 Hz LC stimulation, n=22 neurons across 15 animals, Bonferroni corrected α=0.025, p=0.90 and =4.0 x10-4 respectively, Wilcoxon signed-rank test). Each dot represents a VPm neuron. Error bars indicate ±s.e.m.

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