Supplemetary Figure 2: Trem2 deficiency impairs microglial clustering and CD68 upregulation around cortical plaques.
From: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
a, APPPS1/Trem2+/+ mice show increased microglia clustering around cortical plaques as compared to APPPS1/Trem2-/- and APPPS1/Trem2p.T66M mice. b, Number of IBA1-positive microglia cells quantified per plaque in the cortex (n+/+ = 9 mice, n-/- = 10 mice, np.T66M = 10 mice, F2,26 = 83.07, P = 5.1 × 10–12). c, APPPS1/Trem2+/+ mice show increased CD68-positive microglia clustering around cortical plaques as compared to APPPS1/Trem2-/- and APPPS1/Trem2p.T66M mice. d, Number of CD68-positive microglia cells quantified per plaque in the cortex (n+/+ = 8 mice, n-/- = 6 mice, np.T66M = 6 mice; F2,17 = 109.7, P = 1.9 × 10–10). e, Number of IBA1-positive microglia cells quantified in plaque barren thalamic nuclei (n = 6 mice/genotype; F2,15 = 0.1553, P = 0.8576). Data represent mean ± s.e.m.. One-way ANOVA, Dunnett’s post hoc analysis; n.s. P > 0.05; ***p < 0.0001.
