Supplemetary Figure 4: Confocal images of individual microglia-depleted APPPS1/TK+ and control APPPS1/TK– mice.
From: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
a, IMARIS 3D reconstructed high-resolution confocal images of x34/ApoE/Aβ stained cortical amyloid plaques of control APPPS1/TK- (left) and age-matched microglia-depleted APPPS1/TK + mice (right) (n = 3 mice/genotype). Numbers at the top left of each image indicate three individual mice per group. b, Left: 3D reconstructed image of x34/ApoE/IBA1 staining shows higher ApoE and IBA1 colocalisation in APPPS1/TK- mice indicated by the degree of white merged staining, compared to; right: APPPS1/TK + mice (n = 3 mice/genotype). c, x34/ApoE/GFAP co-staining in APPPS1/TK- mice looks comparable to APPPS1/TK + mice (n = 3 mice/genotype).
