Supplementary Figure 1: PVN-CRFGCaMP6 signal is increased by the onset and is decreased by the offset of exposure to aversive stimuli.
From: Rapid, biphasic CRF neuronal responses encode positive and negative valence
a–c, PETH plot (upper) and heat map (bottom) from a representative animal shown in Fig. 1d to the onset of TRT (a), in Fig. 1f to the onset of overhead object (b), and in Fig. 1f’ to the onset of visual looming disk (c). e–g, PETH plot (upper) and heat map (bottom) for population activity across animals to the offset of TRT (e), the offset of overhead object (f), and the offset of visual looming disk (g). d,h, PETH plot (upper) and heat map (bottom) from a representative animal shown in Fig. 1f’, aligned to the onset of flight behavior (d) and population activity across animals (h). Data are presented as mean (solid line) ± s.e.m (shaded area). Related to Fig. 1.
