Supplementary Figure 7: DAM increase as APP/PS1 mice age and are absent in non-transgenic littermates. | Nature Neuroscience

Supplementary Figure 7: DAM increase as APP/PS1 mice age and are absent in non-transgenic littermates.

From: A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Supplementary Figure 7

(a) Schematic representation showing the sorting of CD45+ cells from whole brains of 16-month-old APP/PS1 transgenic mice and their age-matched non-transgenic littermates. CD45+ cells were used for scRNA-seq. (b) tSNE plot of 6.095 CD45+ cells pooled from the whole brains of 16-month-old APP/PS1 transgenic mice and age-matched non-transgenic littermates. (c) similar to (b) with colors matching the tissue origin of the cells. blue: WT littermates; red: APP/PS1 transgenic mice. (d) tSNE plots showing the exclusive expression of DAM genes in DAM population of APP/PS1 mice.

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