Supplementary Figure 2: Neuronal responses do not merely reflect licking. | Nature Neuroscience

Supplementary Figure 2: Neuronal responses do not merely reflect licking.

From: Single-cell activity tracking reveals that orbitofrontal neurons acquire and maintain a long-term memory to guide behavioral adaptation

Supplementary Figure 2

An example behavioral session is shown (same as the one in which the neuron shown in Fig. 1h was recorded) from which individual trials of CS+ and CS- presentation were sorted based on the delay to first lick after cue presentation (left grayscale graph). Neuronal responses are plotted for 11 example neurons with the order of trials maintained based on the delay to first lick (also true for the neuron in Fig. 1h). A total of 20 s around the cue is plotted, including a 3 s baseline period prior to trial start. Any overlap between trials is removed, resulting in the trailing white space on some trials. Comparison of neuronal responses to the licking behavior shows that neuronal responses are not merely a consequence of licking behavior. Further, it can be seen that there is considerable trial-to-trial variability in neuronal responses.

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