Supplementary Figure 6: Lewy pathology as identified by CLEM.
From: Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
Projections of the central 20 slices of each reconstructed 3D tomogram are shown for each aSyn-immunopositive inclusion and surrounding cellular milieu. Feature details (arrowheads) are tabulated in Supplementary Table 1. Additional aSyn-immunopositive Lewy pathological inclusions are shown in Figs. 3, 4 and Supplementary Fig. 5–12. Donor identities are shown in Table 1. (a) aSyn-immunopositive inclusion in Donor A-PD (Movie 5), (b, c) in Donor B-PD (Supplementary Movies 6, 7), (d–f) in Donor D-PD (Movies 8–10, CLEM data Supplementary Fig. 3b-d). Scale bars = 1 µm.
