Supplementary Figure 9: Membranous Lewy pathology within neuromelanin-containing organelles.
From: Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
Identified by CLEM in Donor E-PD. CLEM data shown in Supplementary Fig. 3f 2D electron micrographs showing the ultrastructure of a predominantly membranous aSyn-immunopositive inclusion at (a) low magnification (white dotted circle) in which it can be seen amongst neuromelanin-containing organelles (black high contrast spots), and increasingly higher magnification in (b, c). Abundant clustered mitochondria (vesicles with cristae) are interspersed amongst the other notated features. Scale bars: a = 5 µm; b = 2 µm; c = 1 µm.
