Supplementary Figure 1: Histopathalogical analysis of PD brain donors.
From: Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
(a–d) Immunohistochemical analysis of aSyn pathology. aSyn (KM-51) immunostaining in the CA2 region of the hippocampus of Donor A-PD. (e–h) aSyn (KM-51) immunostaining of the substantia nigra of Donor B-PD. Images shown are from tissues that were taken from the same region of the same brain donors used for the other methods employed in this study, including CLEM and SBFSEM. Scale bars = 50 µm. (i–l) Conventional histopathological aspect of FFPE sample of the substantia nigra obtained from a PD brain donor shows Lewy pathology and corpora amylacea side by side. H&E stained tissue sections; yellow arrowheads indicate CA; black arrowheads indicate Lewy bodies. Note the similar size of the two structures and that they can occur in close proximity to one another. Scale bars: i-k = 10 µm; l = 20 µm.
