Supplementary Fig. 9: Chase Also Increases Density of Axons Originating in Right Motor Cortex.
From: Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury
(a) A488-traced CST axons originating in the right motor cortex; 90% of these axons cross midline at the medullary pyramids and descend in the intact left hemicord, hence the greater density of descending axons compared to Fig 4. (b) Some of the axons cross midline near the central canal (CC) and (c) terminate primarily in the ventromedial gray matter. (d) Ventromedial gray matter from control subject. (e) Quantification shows that, just as with axons originating in the left motor cortex, Chase increases the density of these CST axons caudal to the spinal cord hemisection (total length in lesion-side GM per 40 μm section; P=0.001, linear mixed model). Immunolabeling and quantification included N=6 Chase and N=5 controls. Bars represent means, data points are individual subjects, error bars represent linear mixed model SEM. Scale bars: A,1 mm; B-D, 100 μm.
