Supplementary Figure 13: Validation of the quality assurance pipeline.
From: Common brain disorders are associated with heritable patterns of apparent aging of the brain
A sample of 1521 individuals was manually quality controlled and data from individuals marked for in- or exclusion. This method was compared against Euler numbers (a-b) and against automated decisions based on data deceeding 3 (c) or 1 (d) standard deviation in Euler numbers. Together, these results confirm that Euler number is sensitive to data quality and can be used for automated quality control. We used 3 SD as the criterion for the main analysis, allowing us to exploit the full sample size at the risk of missing a proportion of outliers. To mitigate this risk, we also provide a re-analysis of the data in the supplement using 1 SD as the exclusion criterion. Panels a-b report t-statistics and two-sided P-values from one t-test per hemisphere. The whiskers in the boxplot extend from the hinge to the largest/smallest value no further than 1.5 * IQR from the hinge. The horizontal mid line depicts the median.
