Supplementary Figure 6: Case-control differences on principal components in the test sets.
From: Common brain disorders are associated with heritable patterns of apparent aging of the brain
This analysis quantifies variance in the features in relation to case-control differences. We conducted a PCA in each test sample, yielding components that capture the variance across the 1118 brain imaging features, and assessed case-control differences in models accounting for age, age², sex, scanning site and Euler number. Except for MDD and SZRISK, all test samples showed significant case-control differences (black boxes indicate p < FDR; Benjamini-Hochberg; two-sided). The test samples with cases and matched controls comprised n=925 ASD / n=925 HC, n=725 ADHD / n=725 HC, n=94 SZRISK / n=94 HC, n=1110 SZ / n=1110 HC, n=300 PSYMIX / n=300 HC, n=459 BD / n=459 HC, n=254 MS / n=254 HC, n=208 MDD / n=208 HC, n=974 MCI / n=974 HC, n=739 DEM / n=739 HC; in total n=10,141 independent subjects.
