Supplementary Figure 4: Immunoglobulin G localization in the CNS. | Nature Neuroscience

Supplementary Figure 4: Immunoglobulin G localization in the CNS.

From: Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

Supplementary Figure 4

Representative images of brain/spinal cord sections immunostained for endogenous immunoglobulin G (IgG) in control and subacute mice. Peripherally synthesized IgG is increased in seizure, EAE, stroke and TBI disease models (B,D,F,H) compared to controls (A,C,E,G). Scale bars: 200 microns; 100 microns in EAE. n=number of mice (Control/Subacute): Seizure: 3/5, EAE: 2/3, Stroke: 4/4, TBI: 3/3.

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