Supplementary Figure 6: Expression of collagen I in the CNS. | Nature Neuroscience

Supplementary Figure 6: Expression of collagen I in the CNS.

From: Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

Supplementary Figure 6

Representative images of brain/spinal cord sections immunostained for extracellular matrix protein collagen I (red) and vessel marker CD31 (green) in control and subacute mice. Collagen I colocalized with CD31 is increased in seizure, EAE, stroke and TBI disease models (B,D,F,H) compared to controls (A,C,E,G). Arrow in seizure model control (A) highlight an example of a medium size vessel without collagen expression. Dense DAPI labeling in EAE subacute identify a lesion. Arrowheads highlight examples of ectopic expression of collagen I colocalized with CD31+ vessels. Scale bars: 50 microns. n=number of mice (Control/Subacute): Seizure: 3/4, EAE: 4/3, Stroke: 4/4, TBI: 3/3.

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