Supplementary Figure 2: THC-induced deficits of PPI are age-dependent.
From: Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone
(a) Effect of THC challenge on PPI in CTRL and PCE young male adult (PND 60-70) offspring (P=0.64, ns, F(1,27)=2.5; two-way ANOVA; nrat= 8 per CTRL-VEH, CTRL-THC and PCE-VEH groups; nrat= 7 per PCE-THC group; nlitter= 6 per group). Data are represented as box-and-whiskers plot (including minima, maxima, and media values, and lower and upper quartiles) with single values. (b) Representative photograph of the probe location into the nucleus accumbens shell. The arrow indicates the tip of the probe. N= 7 experiments per group were repeated independently, with similar results obtained. (c) Schematic diagram of the cerebral area targeted by the microdialysis probe as indicated by the vertical line (nucleus accumbens shell, AP: +1.5, L: ±0.7, V: -7.0 from bregma) from Paxinos and Watson (2007). (d) Schematic showing the approximate localization of the probe for the experiments shown in Fig. 1c. NAcSh, nucleus accumbens shell; NAcC, nucleus accumbens core; CPu, caudate/putamen.
