Extended data Fig. 10: Gene regulatory network analysis predicts transcription factors regulating GWAS genes for conversion of control to AD subcluster signatures. | Nature Neuroscience

Extended data Fig. 10: Gene regulatory network analysis predicts transcription factors regulating GWAS genes for conversion of control to AD subcluster signatures.

From: A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

Extended data Fig. 10

Trajectories of the top transcription factors (TFs): NKX6–2, ETS2, ZKSCAN1, HIF3A, GTF2IRD1, RELA, SOX10, KDM5B and MAX, with downstream GWAS gene targets. For each cell type, the reported TFs-driven gene regulatory networks include GWAS gene hits, which are direct target genes of the TF and have the highest average log fold change in gene expression between the source subcluster/s and target subcluster/s. Each gene is colored according to its average log fold change between the source subcluster/s and target subcluster/s. Only significantly differentially expressed GWAS gene hits are reported (false discovery rate < 0.05).

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