Extended data Fig. 2: Single nuclei metadata and analysis of hybrid cells. | Nature Neuroscience

Extended data Fig. 2: Single nuclei metadata and analysis of hybrid cells.

From: A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

Extended data Fig. 2

a, cell proportion plots by library for eight libraries showing exclusion of two libraries due to high neuronal count and comparison of cell type proportions recovered in this study compared to cell proportions in other single nuclei studies24 and52. Cell proportions are shown by sequencing library, where this information is available. b, Frequency histogram of number of Unique Molecular Identifiers (UMIs) across all 8 cell type groups. c, Frequency histogram of number of detected genes across all 8 cell type groups. d, Barplot showing number of top two identified cell types in hybrid cell types in AD and control libraries as proportion. e, UpSetR69 plot showing the BRETIGEA number of distinct and overlapping cell type markers across the six major cell types - microglia, astrocyte, neuron, oligodendrocyte, OPC, and endothelial cells.

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