Extended Data Fig. 7: Comparison of PK-resistant α-syn species generated from recombinant α-syn fibril strains with α-syn species in brain homogenates from fibril-inoculated TgM83 mice. | Nature Neuroscience

Extended Data Fig. 7: Comparison of PK-resistant α-syn species generated from recombinant α-syn fibril strains with α-syn species in brain homogenates from fibril-inoculated TgM83 mice.

From: α-Synuclein strains target distinct brain regions and cell types

Extended Data Fig. 7

Immunoblot of detergent-insoluble α-syn species following digestion of recombinant fibrils or brain homogenates from fibril-inoculated TgM83 mice (first passage) with PK. PK-resistant α-syn was detected using the antibody Syn-1.

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