Extended Data Fig. 4: General translation inhibition in CamK2α principal neurons. | Nature Neuroscience

Extended Data Fig. 4: General translation inhibition in CamK2α principal neurons.

From: Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

Extended Data Fig. 4

Blocking protein synthesis in CamK2α principal neurons in LA did not affect acclimation to a novel environment (a), total locomotor activity (b) or thigmotaxis, assessed by % distance traveled in center compared to total distance (c). d) In the elevated plus maze, however, animals with protein synthesis blocked in CamK2α principal neurons exhibited reduced anxiety i.e. increased %open arm duration (*p<0.05) compared to vehicle treated CamK2α iPKR mice and CamK2α wildtype mice even though they make equivalent entries to the open arm (e). n = 4-5 per group. RM Two-way ANOVA for a), One-way ANOVA followed by Bonferroni’s post-hoc test for (b), (c), (d) and (e).

Back to article page