Extended Data Fig. 8: Model for protein synthesis regulation during long-term memory consolidation.

a) In wild-type mice, threat conditioning leads to a spatiotemporally regulated increase in somatic and dendritic protein synthesis that stabilizes the memory trace. b) Application of ciPSI system prevents the coordinated increase in cell-wide translation leading to impaired LTM. c) Dephosphorylation of eIF2α enhances general translation, but it is dysregulated and unable to coordinate the cell-wide translation program to store a complex memory trace, resulting in memory generalization. d) Artificial reactivation of the amygdala principal neurons after protein synthesis inhibition-mediated amnesia leads to an increase in translation but does not restore synapse specificity and thus leads to memory generalization.