Extended Data Fig. 2: Overall myelination status and microglial density are unchanged in the absence of new myelin formation.
From: Preservation of a remote fear memory requires new myelin formation
a, Representative images of ASPA (green) staining in the PFC of cre-negative and Myrf icKO mice 30 days post-conditioning, quantified in (b); unpaired two-tailed t-test, difference: -26.50 ± 26.20, 95% CI: -81.15 to 28.15, t20 = 1.012, p = 0.3238, n = 11 mice per genotype. c, Representative images of MBP (gray) staining in the PFC of cre-negative and Myrf icKO mice 30 days post-conditioning, quantified in (d); unpaired two-tailed t-test, difference: 0.1927 ± 12.13, 95% CI: -25.12 to 25.50, t20 = 2.406, p = 0.9875, n = 11 mice per genotype. e, Representative images of Iba1 (magenta) staining in the PFC of cre-negative and Myrf icKO mice 30 days post-conditioning, quantified in (f); unpaired two-tailed t-test, difference: -3.698 ± 29.55, 95% CI: -69.53 to 62.14, t10 = 0.1251, p = 0.9029, n = 6 mice per genotype. Scale bars: 100 μm (a,c,e). Data are presented as mean ± SEM.
