Extended Data Fig. 5: Responses of CA1 and CA2 neurons to novel stimuli. | Nature Neuroscience

Extended Data Fig. 5: Responses of CA1 and CA2 neurons to novel stimuli.

From: Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model

Extended Data Fig. 5

a, Color-coded z-scored firing rates in the interaction zone around the novel mouse (session 4) and familiar mouse (sessions 3 and 5) for 87 CA1 neurons (n = 3 mice). There was no significant difference in firing rates among sessions (ANOVA, p = 0.17). b, Cumulative distributions of z-scored firing rates for all 192 CA2 neurons (n = 6 mice) in the interaction zones in each session of the five 3-chamber task sessions. CA2 activity in the interaction zones was significantly different among the different sessions (Kruskal Wallis test; p < 0.0001). CA2 firing rates in interaction zone around the novel object (wire cup cage) were significantly greater than in same spatial location in empty chamber (two-sided Mann-Whitney test, p = 0.02). CA2 firing rates around the novel mouse were significantly higher than around the novel object (mean z-scored firing rates=0.83 ± .06 and 0.19 ± 0.08, respectively; two-sided Mann-Whitney test, p = 0.56).

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