Extended Data Fig. 5: Development of focal GiD (fGiD). | Nature Neuroscience

Extended Data Fig. 5: Development of focal GiD (fGiD).

From: Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production

Extended Data Fig. 5

a, b, Schematic diagram and experimental procedure for making mild and severe focal GiD, fGiDm and fGiDs, respectively. c, Immunostaining for GFAP and mCherry in CTL, fGiDm and fGiDs. d, Quantification for GFAP intensity in CTL, fGiDm and fGiDs. e, DAPI image in CTL, fGiDm and fGiDs. f, Counting the number of DAPI signals in stratum radiatum of CTL, fGiDm and fGiDs. g, Measuring the size of CA1 region in CTL, fGiDm and fGiDs. h, Comparison of glial activation in hippocampus between fGiDs and GiDs. Data are presented as mean ± SEM. **P < 0.01, ***P < 0.001, ****P < 0.0001; NS: not significant. Additional statistical details are provided in Supplementary Table 1.

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