Extended Data Fig. 3: MAO-B-mediated astrocytic hypertrophy and lack of neurodegeneration in GiDm brain. | Nature Neuroscience

Extended Data Fig. 3: MAO-B-mediated astrocytic hypertrophy and lack of neurodegeneration in GiDm brain.

From: Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production

Extended Data Fig. 3

a, Experimental procedures for AAD-2004 and selegiline treatment in GiDm. b,c, Immunostaining and quantification for GFAP in Gcon, GiDm, selegline-treated GiDm and AAD-2004-treated GiDm. d,e, Immunostaining and quantification for NeuN in Gcon and GiDm. Data are presented as mean ± SEM. ***P < 0.001, ****P < 0.0001; NS: not significant. Additional statistical details are provided in Supplementary Table 1.

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