Extended Data Fig. 2: Ush2a-/- mice have a mild hearing deficit in a paired-pulse inhibition behavioral task.
From: USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans
a, Response amplitudes (in arbitrary units) of Ush2a+/+ (n=10) and Ush2a-/- (n=9) mice to 20-40ms auditory tones of different amplitudes did not differ (Two-way repeated-measures ANOVA analysis F(1,18)=2.937, P=0.10). b, Lower amplitude tones reduced the startle response when given 200ms before the startling 129dB tone in both Ush2a+/+ (n=10) and Ush2a-/- (n=9) mice, however the amplitude of the response was significantly lower in Ush2a-/- mice compared to Ush2a+/+ mice at 73dB and 81bD pre-pulse tones; two-way repeated-measures ANOVA F(1,18)=2.711, P=0.006, asterisks indicate Bonferroni post-hoc analyses *P < 0.01. Data = mean ± s.e.m.
