Fig. 3: I-S1 (AMSBIO) is cleared from blood and taken up by peripheral tissues.
From: The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
a, Clearance of I-S1 from AMSBIO from blood. Data were fitted to a one-phase exponential decay model: y = 1.05 (e−0.393t) + 0.880 (half-life of 1.74 min; n = 11 mice; r2 = 0.867). Clearance from blood was linear for the first 10 min, with a half-time clearance of 3.6 min. In b–f, the y axes show the delta tissue/serum ratios for I-S1, corrected for vascular space and nonspecific leakage (Methods). b, The I-S1 Ki value for whole brain was significantly non-zero (P < 0.0001), indicating tissue uptake (n = 11 mice). c–f, The I-S1 Ki values for different tissues calculated based on the linear portions of their curves. c, The I-S1 Ki for lung was significantly non-zero (P < 0.0001; n = 11 mice). d, The I-S1 Ki value for spleen was significantly non-zero (P = 0.002; n = 11 mice). e, The I-S1 Ki value for kidney was significantly non-zero (P = 0.0004; n = 11 mice). f, The I-S1 Ki for liver was significantly non-zero (P = 0.0005; n = 8 mice; n = 3 mice (filled circles) were excluded from regression analysis due to nonlinearity). All error terms are the s.e.m.
