Extended Data Fig. 8: Diencephalic infarcts and reduced monocyte infiltration in Cxcr4cKO mice undergoing tMCAO. | Nature Neuroscience

Extended Data Fig. 8: Diencephalic infarcts and reduced monocyte infiltration in Cxcr4cKO mice undergoing tMCAO.

From: Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke

Extended Data Fig. 8

a, Images demonstrate degenerated areas in the diencephalon of two Cxcr4cKO mice undergoing tMCAO. Segmented lines identify the thalamus and hypothalamus. Arrows point to degenerated/ NeuN−regions. Images are representative for n = 13 mice (day 2) and n = 15 mice (day 3). b, Confocal images of NeuN/ Iba1/ tdT immunofluorescences in a Cxcr4-control (ctrl) and a Cxcr4cKO (cKO) at day 1 after tMCAO. Segmented lines identify the infarct area. High magnification images were photographed in the NeuN+ peri-infarct area in the olfactory tubercle. Images are representative for n = 6 mice each. Abbreviations: CPu, caudate putamen; hTh, hypothalamus; oTb, olfactory tubercle; Th, thalamus. Scale bars: 500 µm (a); 500 µm and 30 µm (b).

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