Extended Data Fig. 9: Clustering analysis reveals three distinct populations of VS MSNs, which differ in their response profiles and correlation patterns.
From: Dissociable roles of ventral pallidum neurons in the basal ganglia reinforcement learning network
a, MSN responses to cue events. Each row is the Z-score transformed PSTH of a single neuron to the presentation of cues that signal rewarding, neutral or aversive outcomes. Z-scores are color-coded. Abscissa, time (0–2 s), zero is the time of cue onset; ordinate, unit number. Cells are ordered by clusters. Within each cluster, cells are randomly ordered. N = 394 neurons. b, Top: MSN population responses to cue presentations. Abscissa, time (-0.5 – 2 s). The vertical dashed lines at t = 0 indicate the time of cue onset; ordinate, normalized firing rate in Hz. Blue, reward trials; green, neutral trials; red, aversive trials. Shaded regions represent SEMs. Bottom: MSN absolute population responses to cue presentations. N = 163, 85 and 146 neurons, from left to right. c, Top: mean cross-correlation histograms. N = 99, 34 and 70 pairs, from left to right. Abscissa: time, ±1 s around the trigger spike (time = 0); ordinate: normalized firing rate in Hz. Shaded regions represent SEMs. Bottom: distributions of signal correlations. N = 6771, 1776 and 5257 pairs, from left to right.
