Extended Data Fig. 1: LHb non-conditional fiber photometry supporting data.
From: Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice

a, AGG average LHb activity was reduced following a bite on day 1 of RI (two-tailed paired t-test, n = 5 biologically independent mice, 3–5 bites per mouse, t(4)=3.763, p = 0.0197). b, AGG average LHb activity was increased following a withdrawal from aggression on day 1 of RI (two-tained paired t-test, n = 5 biologically mice, 3–5 withdrawals per mouse, t(4)=3.229, p = 0.03). c, AGG average LHb activity did not differ before and after random time points during RI on day 3 (two-tailed paired t-test, n = 5 biologically independent mice, t(4)=0.6545, p = 0.5485). d, NON average LHb activity was not significantly increased following intruder approach on day 1 of RI (two-tailed paired t-test, n = 5 biologically independent mice, 3-5 approaches per mouse, t(4)=2.25, p = 0.087). e, NON average LHb activity was not significantly reduced following withdrawal from social interactions on day 1 of RI (two-tailed paired t-test, n = 5 biologically independent mice, 3-5 withdrawals per mouse, t(4)=2.353, p = 0.078). f, NON average LHb activity did not differ before and after random time points during RI on day 3 (two-tailed paired t-test, n = 5 biologically independent mice, 5 time points per mouse, t(4)=0.553, p = 0.6221). g, AGGs used for fiber photometry experiments displayed significantly higher aggression CPP scores than NONs (two-tailed student’s t-test, n = 4 biologically independent mice per group, t(6)=5.591, p = 0.0014). h, LHb peaks in the intruder paired context during the CPP preference test were negatively correlated with CPP score (two-tailed student’s t-test, n = 8 biologically independent mice, Pearson correlation coefficient = -0.94, R2 = 0.88, p = 0.0005). *p < 0.05, **p < 0.01. All data are expressed as mean ± SEM.