Extended Data Fig. 7: Expression differences between iMG genotypes upon zymosan challenge. | Nature Neuroscience

Extended Data Fig. 7: Expression differences between iMG genotypes upon zymosan challenge.

From: Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

Extended Data Fig. 7

Fluidigm mRNA analysis of indicated iMG genotypes treated with vehicle or zymosan (50 µg/ml) for 24 hours. Heatmap and mRNA expression fold changes of cytokine and chemokine genes identified to be responsive to zymosan challenge in WT iMG. Fold change values of downregulated genes appear in red. n = 3 biologically independent experiments. Adjusted P-values are presented; one-way ANOVA, post-hoc Tukey test for multiple comparisons.

Back to article page