Extended Data Fig. 2: Cerebrovascular and electrophysiological parameters in male and female 16p11.2df/+ and WT mice at P14 and P50.
From: Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice
a, LDF recording (Tissue perfusion units, mean ± s.e.m.) of resting state CBF over the primary somatosensory cortex from anesthetized mice, averaged over 40 sec. b, Quantification and comparison of resting state CBF using LDF in all groups of mice. c,d, ECoG recordings in the primary somatosensory cortex from P14 male (c), and P50 female (d) 16p11.2df/+ and WT mice. In c and d: Left, Representative power spectral traces of low-frequency bands (n = 4-5 animals per group; 6 stimulations per animal). Right, Average absolute power in Delta (1-4 Hz), Theta (4-8 Hz), Alpha (8-13 Hz), Beta (13-30 Hz), Low Gamma (35-55 Hz) and High Gamma (65-100 Hz) frequency bands at resting-state (upper panel) and during stimulation (lower panel). Data (right) are mean with individual values (n = 4-5 animals per group; 6 stimulations per animal). Data are mean ± s.e.m. in a, whisker boxes (min to max, center line indicating median) in b, or mean with individual values in c,d (right) (n = 4-6 animals per group). **P < 0.01, ***P < 0.001 (2-way ANOVA and Tukey’s post-hoc test in b).
