Extended Data Fig. 9: Tet2 inactivation protects against LPS induced motor learning deficits. Behavioral analysis in wild-type and Tet2 knockout mice 8 and 10 months after exposure to LPS or saline.
From: Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective
a, Rotarod learning assessed in wild-type and Tet2 knockout mice 8 months post-LPS or saline injection (*P = 0.04, **P < 0.01, repeated measures ANOVA). b, Rotarod analysis of wild-type and Tet2 knockout mice at 10 months post-LPS or saline injection. Open field analysis of wild-type and Tet2 knockout mice at (c) 8 months and (d) 10 months post-LPS or saline injection. Gait analysis using the CatWalk system for wild-type and Tet2 knockout mice measuring (e, f) average speed or (g, h) cadence at 8 months and 10 months post-LPS or saline injection. a‒h, All statistical analyses were performed using a two-way or repeated measures ANOVA followed by post hoc Tukey HSD test. 8 month: n = 11 wild-type + saline, 7 wild-type + LPS, 13–14 Tet2 knockout + saline, 11 Tet2 knockout + LPS; 10 month: n = 11 wild-type + saline, 7 wild-type + LPS, 11–12 Tet2 knockout + saline, 8 Tet2 knockout + LPS. Error bars representing s.e.m.
