Extended Data Fig. 3: WGCNA highlights modules associated with memory oscillations.
From: Gene-expression correlates of the oscillatory signatures supporting human episodic memory encoding

a, Representative network dendrogram for the consensus WGCNA. Heatmap shows the correlation between memory oscillatory signatures and genes. Red = positively correlated, Blue = negatively correlated. b, Heatmap showing the module association between memory oscillatory signatures and module eigengenes (Spearman’s rank correlation). Warm colors represent positive correlations and cool colors represent negative correlations. P-values for each correlation together with exact correlation values are contained within each box. c, Bubble-chart showing the enrichment for 300 SME genes decomposed by brain oscillation. Gradient color represents the -log10(FDR) and bubble size represents the odds ratio (OR) from a Fisher’s exact enrichment test of each module with disease-relevant gene lists. Y-axis shows the brain oscillations labels. X-axis indicates the modules of the present study. d, Boxplots showing the differential connectivity (for example number of edges) between SME genes and non-SME genes in the modules associated with memory oscillatory signatures with SME genes enriched. Stars correspond to the results of a Wilcoxon’s rank sum test (one-side test with alternative greater; p < 0.001 = ****, p < 0.01 = **, p < 0.05 = *; Benjamini-Hochberg adjusted: WM4, FDR = 0.016, WM12, FDR = 0.048, WM21, FDR = 4.5x10-4). Boxes extend from the 25th to the 75th percentiles and the center lines represent the median.