Extended Data Fig. 4: Morphology of newly generated neurons in different brain regions, 2 months post-PTB-ASO ICV administration. | Nature Neuroscience

Extended Data Fig. 4: Morphology of newly generated neurons in different brain regions, 2 months post-PTB-ASO ICV administration.

From: Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

Extended Data Fig. 4

Representative images of (left) granule cell layer, (middle) CA1, and (right) cortex, 2 months post-ICV injection of PTB-ASO2 into mice carrying both a CAG-lox-stop-lox-tdTomato gene and a tamoxifen-inducible GFAP-CreERT2 transgene. (Red) tdTomato (visualized by direct fluorescence); (blue) DAPI staining for DNA; experiment was reproduced three times, independently, with similar results.

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