Extended Data Fig. 10: tdTomato + , DCX + cells convert to expression of NeuN within 2 months of PTB ASO injection.
From: Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB
Quantification of total tdTomato + , NeuN+ positive cells per dentate gyrus area of 5 months old mice 2 weeks or 2 months post PTB-ASO or control ICV injection into mice Data are presented as mean +/− s.e.m. (control: 1.33 +/− 0.66; 2 weeks PTB-ASO mean: 3.16 +/− 1.59; 2 months PTB-ASO mean: 28.88 +/− 4.87; n = 3, n = 3, n = 4, respectively; **, One way ANOVA with Tukey’s multiple comparisons, **p = 0.0013).
