Extended Data Fig. 9: Scopolamine does not affect CREB phosphorylation.
From: Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation
pCREB levels were measured in the hippocampus of C57BL/6J mice with Western blot analysis 8 hrs and 24 hrs after scopolamine treatment. No significant differences were observed between Sal- and SCA-treated groups at either time point (two-sided unpaired t-test or Welch’s correct t-test, 8 hrs: t(9.272) = 0.9004, P = 0.3907, n = 8 mice per group, 24 hrs: t(12) = 0.0677, P = 0.9472, n = 7 mice per group). The Graph represents mean ± S.E.M., N.S.: not significant, Sal: Saline, SCA: Scopolamine. For detailed statistical information, see Supplementary Table 1.
