Extended Data Fig. 1: Gene expression and chromatin features of LADs identified by GO-CaRT in 3T3 MEFs.
From: Distinct nuclear compartment-associated genome architecture in the developing mammalian brain
a, Venn diagram showing percent overlap of LAD coverage between GO-CaRT and DamID in MEFs. b, Box and whiskers plot depicting average gene expression (RNA-seq- SRX803943, SRX803944) in LADs and inter-LADs defined by GO-CaRT and DamID in MEFs. P = Two-tailed student’s t-test. GO-CaRT LADs, n = 4390, inter-LADs, n = 30499; DamID LADs, n = 5313, inter-LADs, n = 29576, n = number of genes. Boxes show the range from lower (25th percentile) to upper quartiles (75th percentile), with the median line (50th percentile); whiskers extend 1.5 times the inter-quartile range from bounds of box. c-e, Average H3K9me2 (c), H3K9me3 (d) and H3K27me3 (e) signal over LADs and flanking regions (400 Kb). Average LaminB signal (red) is also shown in each plot.
