Extended Data Fig. 2: Gene density and expression in LADs identified in mouse brain NPCs in vivo.
From: Distinct nuclear compartment-associated genome architecture in the developing mammalian brain
a, Circos plot showing LaminB enrichment and LADs (horizontal bars) across the mouse chromosomes (1-19) in dorsal and ventral NPCs. b, LAD and inter-LADs gene density in brain NPCs (GO-CaRT) and indicated cultured cell lines (DamID). ASCs, astrocytes., ESCs, embryonic stem cells. c, Box plot depicting average gene expression in LADs (dorsal, n = 3683; ventral, n = 3520) and inter-LADs (dorsal, n = 18849; ventral, n = 19014) as determined by RNA-seq in dorsal and ventral NPCs, n = number of genes. P = Two-tailed students t-test. Boxes show the range from lower (25th percentile) to upper quartiles (75th percentile), with the median line (50th percentile); whiskers extend 1.5 times the inter-quartile range from bounds of box.
