Extended Data Fig. 7: Gene ontology analysis of neuronal subtype clusters.
From: Identification of neural oscillations and epileptiform changes in human brain organoids
Top 10 most enriched Gene Ontology biological process (GO BP) terms associated with upregulated or downregulated differentially expressed genes when comparing Mut and iCtrl within the main excitatory (CPN and CFuPN) and interneuron (IN) clusters. Upregulated genes in the excitatory clusters are highly enriched for terms associated with synaptogenesis and axonal morphogenesis while downregulated genes are associated with mRNA catabolism and translation. In contrast, synaptogenesis terms are absent among the upregulated genes in the IN cluster, with this set populated by terms associated with forebrain differentiation and axonal morphogenesis. Downregulated genes in the IN cluster are enriched for metabolism and cellular cytoskeleton associated terms.
