Extended Data Fig. 4: MAGMA gene-based association analysis. | Nature Neuroscience

Extended Data Fig. 4: MAGMA gene-based association analysis.

From: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Extended Data Fig. 4

Manhattan plot of the –log10(P from a one-sided Z-test) of 18,093 genes that were tested for association in the MAGMA (v.1.08) gene-based association analysis (Supplementary Information section 6). The 10 most significant genes are labeled with gene names. Red dashed line represents Bonferroni-significance, adjusted for the number of tested genes (one-sided P = 2.74 × 10–6). 928 genes were found to be significant, of which 244 have one or more genome-wide significant SNPs from the externalizing GWAS within their gene breakpoints. The results are also report in Supplementary Table 13.

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